Monitoring Serum Creatinine, Blood Urea Nitrogen in Patients Brain Injury with Mannitol Therapy

Increased intracranial pressure is a further effect of brain injury due to structural damage and osmotic water imbalances (Edema). Mannitol works in the proximal tubules mannitol absorption tubular cells by mechanism pinocytosis. The fluid transfer will draw into intracellular, so that cell be switched broke. This phenomenon referred as "Nephrosis Osmotic", which administration may occur result accumulation drugs kidneys prolonged exposure kidney given dosage. effects diuresis occurring plus dose duration are reported cause renal function disorders (Scr BUN). aim this study was analyze changes serum creatinine BUN patients with from before receiving therapy during treatment. From results number who met inclusion criteria, 32 patients. Serum creatinine, initial average 0.85 ± 0.17 mg / dl last day mean SCr 0.74 0.30 dl. While (Blood Urea Nitrogen) 11.27 2.75 17.08 8.59 Creatinine data it can concluded there no significant change.